compound 3 [Tuttle et al., 2013] [Ligand Id: 8815] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2321944 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046259] [UniProtKB: Q8N5Z0] | ||||||||
| ChEMBL | Irreversible inhibition of human KAT2 using L-kynurenine as substrate measured every 5 mins over 16 hrs by SpectraMax plate reader analysis | B | 8.15 | pKi | 7.1 | nM | Ki | ACS Med Chem Lett (2013) 4: 37-40 [PMID:24900560] |
| ChEMBL | Inhibition of human KAT2 using L-kynurenine as substrate measured after 15-20 hrs by SpectraMax plate reader analysis | B | 7.64 | pIC50 | 23 | nM | IC50 | ACS Med Chem Lett (2013) 4: 37-40 [PMID:24900560] |
| Kynurenine--oxoglutarate transaminase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046260] [UniProtKB: Q6YP21] | ||||||||
| ChEMBL | Inhibition of human KAT3 using L-kynurenine as substrate measured after 24 hrs by SpectraMax plate reader analysis | B | 5.91 | pIC50 | 1230 | nM | IC50 | ACS Med Chem Lett (2013) 4: 37-40 [PMID:24900560] |
| L-Cysteine:2-oxoglutarate aminotransferase/Kynurenine--oxoglutarate transaminase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3962] [GtoPdb: 1445] [UniProtKB: Q16773] | ||||||||
| ChEMBL | Inhibition of human KAT1 using L-kynurenine as substrate measured after 16 hrs by SpectraMax plate reader analysis | B | 5.69 | pIC50 | 2040 | nM | IC50 | ACS Med Chem Lett (2013) 4: 37-40 [PMID:24900560] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
