D-e-MAPP [Ligand Id: 8817] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL429926 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| N-acylsphingosine amidohydrolase 1/Acid ceramidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5463] [GtoPdb: 2491] [UniProtKB: Q13510] | ||||||||
| ChEMBL | Inhibition of aCDase expressed in human HL60 cell extract | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2012) 20: 6162-6170 [PMID:22989912] |
| alkaline ceramidase 2/Alkaline ceramidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331067] [GtoPdb: 2469] [UniProtKB: Q5QJU3] | ||||||||
| ChEMBL | Inhibition of alkaline ceramidase 2 in human HL-60 cells using 3H]C16-ceramide as substrate after 1 hr by liquid scintillation counting analysis | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2013) 21: 874-882 [PMID:23312611] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
