ChEMBL ligand: CHEMBL2442509
Monocarboxylate transporter 4 in Human [ChEMBL: CHEMBL2073663] [GtoPdb: 989] [UniProtKB: O15427] There should be some charts here, you may need to enable JavaScript!
Monocarboxylate transporter 2 in Human [GtoPdb: 990] [UniProtKB: O60669] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Monocarboxylate transporter 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073663] [GtoPdb: 989] [UniProtKB: O15427]
ChEMBL	Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 24 hrs by liquid scintillation counting	B	7.23	pIC50	59	nM	IC50	Bioorg Med Chem (2013) 21: 7107-7117 [PMID:24095010]
ChEMBL	Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 12 mins by liquid scintillation counting	B	8	pIC50	10	nM	IC50	Bioorg Med Chem (2013) 21: 7107-7117 [PMID:24095010]
Monocarboxylate transporter 2 in Human [GtoPdb: 990] [UniProtKB: O60669]
GtoPdb	-	-	7.96	pIC50	11	nM	IC50	Bioorg Med Chem (2013) 21: 7107-17 [PMID:24095010]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]