compound 2 [Maurer et al., 2012] [Ligand Id: 8823] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2203548 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| sirtuin 1/NAD-dependent deacetylase sirtuin 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4506] [GtoPdb: 2707] [UniProtKB: Q96EB6] | ||||||||
| ChEMBL | Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay | B | 5.28 | pIC50 | 5300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 1050-1053 [PMID:24900427] |
| ChEMBL | Inhibition of sirtuin 1 (unknown origin) | B | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2019) 161: 48-77 [PMID:30342425] |
| sirtuin 2/NAD-dependent deacetylase sirtuin 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4462] [GtoPdb: 2708] [UniProtKB: Q8IXJ6] | ||||||||
| ChEMBL | Inhibition of sirtuin 2 (unknown origin) | B | 5 | pIC50 | 10000 | nM | IC50 | Eur J Med Chem (2019) 161: 48-77 [PMID:30342425] |
| ChEMBL | Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay | B | 5.01 | pIC50 | 9700 | nM | IC50 | ACS Med Chem Lett (2012) 3: 1050-1053 [PMID:24900427] |
| ChEMBL | Inhibition of human recombinant Sirt2 using ZMAL as substrate after 4 hrs by fluorescent deacetylase assay | B | 5.55 | pIC50 | 2818.38 | nM | IC50 | Medchemcomm (2012) 3: 167-173 |
| ChEMBL | Inhibition of human recombinant Sirt2 using ZMAL as substrate after 4 hrs by fluorescent deacetylase assay | B | 5.55 | pIC50 | 2800 | nM | IC50 | Medchemcomm (2012) 3: 167-173 |
| sirtuin 5/NAD-dependent protein deacylase sirtuin-5, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163183] [GtoPdb: 2711] [UniProtKB: Q9NXA8] | ||||||||
| ChEMBL | Inhibition of human recombinant N-terminal Strep2-tagged SIRT5 expressed in Escherichia coli BL21 (DE3) using Abz-GVLK(glutaryl)AY(NO2)GV-NH2 as substrate in presence of NAD+ by fluorescence assay | B | 4.6 | pIC50 | 25200 | nM | IC50 | J Med Chem (2018) 61: 2460-2471 [PMID:29494161] |
| ChEMBL | Inhibition of SIRT5 using ZK(suc)A substrate after 1 hr by homogeneous fluorescence assay | B | 5.64 | pIC50 | 2300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 1050-1053 [PMID:24900427] |
| GtoPdb | - | - | 5.64 | pIC50 | 2300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 1050-3 [PMID:24900427] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
