disprocynium24 [Ligand Id: 8826] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL339858 (Disprocynium24) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of MPP+ uptake in OCT1-expressing HEK293 cells | F | 6.96 | pKi | 110 | nM | Ki | Naunyn Schmiedebergs Arch Pharmacol (1996) 354: 320-326 [PMID:8878062] |
| Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Noradrenaline uptake in OCT2-expressing HEK293 cells | F | 7.89 | pKi | 13 | nM | Ki | J Biol Chem (1998) 273: 30915-30920 [PMID:9812985] |
| ChEMBL | TP_TRANSPORTER: inhibition of Serotonin uptake in OCT2-expressing HEK293 cells | F | 7.89 | pKi | 13 | nM | Ki | J Biol Chem (1998) 273: 30915-30920 [PMID:9812985] |
| ChEMBL | TP_TRANSPORTER: inhibition of Adrenaline uptake in OCT2-expressing HEK293 cells | F | 7.92 | pKi | 12 | nM | Ki | J Biol Chem (1998) 273: 30915-30920 [PMID:9812985] |
| ChEMBL | TP_TRANSPORTER: inhibition of Dopamine uptake in OCT2-expressing HEK293 cells | F | 8.29 | pKi | 5.1 | nM | Ki | J Biol Chem (1998) 273: 30915-30920 [PMID:9812985] |
| Organic cation transporter 3/Solute carrier family 22 member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073673] [GtoPdb: 1021] [UniProtKB: O75751] | ||||||||
| GtoPdb | - | - | 7.82 | pKi | 15 | nM | Ki | Nat Neurosci (1998) 1: 349-51 [PMID:10196521] |
| ChEMBL | TP_TRANSPORTER: inhibition of MPP+ uptake in OCT3-expressing HEK293 cells | F | 7.82 | pKi | 15 | nM | Ki | Nat Neurosci (1998) 1: 349-351 [PMID:10196521] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
