compound 2e [PMID: 19013076] [Ligand Id: 8830] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL106820
  • NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760]
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  • Neuronal NOS/Nitric-oxide synthase, brain in Human [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760]
ChEMBL Inhibition of human DDAH1 by plate-reader assay B 5.7 pKi 2000 nM Ki Bioorg Med Chem (2008) 16: 10205-10209 [PMID:19013076]
ChEMBL Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21 cells using NMMA as substrate measured after 30 mins by colder reagent based microplate reader assay B 5.7 pKi 2000 nM Ki J Med Chem (2020) 63: 425-432 [PMID:31841335]
GtoPdb - - 5.7 pKi 2000 nM Ki Bioorg Med Chem (2008) 16: 10205-9 [PMID:19013076]
ChEMBL Inhibition of human DDAH1 by plate-reader assay B 4.89 pIC50 13000 nM IC50 Bioorg Med Chem (2008) 16: 10205-10209 [PMID:19013076]
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
ChEMBL Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrulline B 7 pKi 100 nM Ki Bioorg Med Chem (2008) 16: 6193-6206 [PMID:18477512]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]