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ChEMBL ligand: CHEMBL106820 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760] | ||||||||
ChEMBL | Inhibition of human DDAH1 by plate-reader assay | B | 5.7 | pKi | 2000 | nM | Ki | Bioorg Med Chem (2008) 16: 10205-10209 [PMID:19013076] |
ChEMBL | Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21 cells using NMMA as substrate measured after 30 mins by colder reagent based microplate reader assay | B | 5.7 | pKi | 2000 | nM | Ki | J Med Chem (2020) 63: 425-432 [PMID:31841335] |
GtoPdb | - | - | 5.7 | pKi | 2000 | nM | Ki | Bioorg Med Chem (2008) 16: 10205-9 [PMID:19013076] |
ChEMBL | Inhibition of human DDAH1 by plate-reader assay | B | 4.89 | pIC50 | 13000 | nM | IC50 | Bioorg Med Chem (2008) 16: 10205-10209 [PMID:19013076] |
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
ChEMBL | Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrulline | B | 7 | pKi | 100 | nM | Ki | Bioorg Med Chem (2008) 16: 6193-6206 [PMID:18477512] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]