compound 1 [PMID: 16821802] [Ligand Id: 8873] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL463223 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Haem oxygenase 1 in Human [GtoPdb: 1441] [UniProtKB: P09601] | ||||||||
| GtoPdb | Enzyme isolated from human spleen. | - | 5.82 | pKi | 1500 | nM | Ki | J Med Chem (2006) 49: 4437-41 [PMID:16821802] |
| Haem oxygenase 1/Heme oxygenase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5035] [GtoPdb: 1441] [UniProtKB: P06762] | ||||||||
| ChEMBL | Inhibition of heme oxygenase-1 in Sprague-Dawley rat spleen microsomal fraction assessed as carbon monoxide formation by gas chromatography | B | 6.1 | pIC50 | 800 | nM | IC50 | Bioorg Med Chem (2009) 17: 2461-2475 [PMID:19268600] |
| GtoPdb | Enzyme isolated from rat spleen. | - | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2006) 49: 4437-41 [PMID:16821802] |
| Haem oxygenase 2 in Rat [GtoPdb: 1442] [UniProtKB: P23711] | ||||||||
| GtoPdb | Enzyme isolated from rat brain. | - | 3.52 | pIC50 | 305000 | nM | IC50 | J Med Chem (2006) 49: 4437-41 [PMID:16821802] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
