ChEMBL ligand: CHEMBL2337806
INPPL1/Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 in Human [ChEMBL: CHEMBL2331064] [GtoPdb: 1459] [UniProtKB: O15357] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
INPPL1/Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331064] [GtoPdb: 1459] [UniProtKB: O15357]
ChEMBL	Inhibition of human SHIP2 (419 to 732 residues) expressed in Escherichia coli by malachite green phosphate assay	B	6.36	pKi	440	nM	Ki	J Med Chem (2021) 64: 3813-3826 [PMID:33724834]
ChEMBL	Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate incubated for 20 mins measured using microplate reader	B	5.82	pIC50	1500	nM	IC50	J Med Chem (2021) 64: 3813-3826 [PMID:33724834]
ChEMBL	Inhibition of SHIP2 (unknown origin)	B	6.21	pIC50	620	nM	IC50	Eur J Med Chem (2013) 62: 649-660 [PMID:23434638]
GtoPdb	IMeasured in a high-throughput screening assay.	-	6.21	pIC50	620	nM	IC50	Br J Pharmacol (2009) 158: 879-87 [PMID:19694723]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]