enoxacin [Ligand Id: 8882] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL826 (AT-2266, CI-919, Comprecin, Enoxacin, Flumark, NSC-629661, NSC-758416, PD 107779, PD-107779, Penetrex) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DNA gyrase subunit A/DNA gyrase subunit B/DNA gyrase in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094139] [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6] | ||||||||
| ChEMBL | Inhibition of Escherichia coli DNA gyrase GyrA/GyrB | B | 4.85 | pIC50 | 14000 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 2909-2914 [PMID:18426901] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | DNDI: Malaria in Vitro, 72 hour | F | 4.11 | pIC50 | 76800 | nM | IC50 | Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning |
| ChEMBL | Antimalarial activity against blood stage form of Plasmodium falciparum assessed as incorporation of [3H]hypoxanthine after 72 hrs by liquid scintillation counting | F | 4.7 | pIC50 | 20000 | nM | IC50 | Eur J Med Chem (2014) 77: 280-287 [PMID:24650715] |
| TAR RNA binding protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2098] [UniProtKB: Q15633] | ||||||||
| ChEMBL | Enhancement of His6-tagged TRBP (unknown origin) expressed in Escherichia coli BL21(DE3) binding to 32P-labeled Let7 precursor RNA assessed as TRBP Kd at 30 uM incubated for 60 mins by liquid scintillation counting method (Rvb = 221 nM) | B | 7.03 | pKd | 94 | nM | Kd | J Med Chem (2020) 63: 12275-12289 [PMID:32672457] |
| V-type ATPase V1 motor B2 subunit/V-type proton ATPase subunit B, brain isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5641] [GtoPdb: 812] [UniProtKB: P21281] | ||||||||
| GtoPdb | Measuring inhibition of the interaction between the profilin-like domain of the B2 subunit and F-actin. | - | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5144-51 [PMID:19630402] |
| ChEMBL | Inhibition of maltose binding protein-fused human V-ATPase subunit B2 binding to F-actin | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5144-5151 [PMID:19630402] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
