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ChEMBL ligand: CHEMBL3785909 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
GtoPdb | Biochemically assessed value. | - | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6307-12 [PMID:19819693] |
ChEMBL | Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 mins by electrochemiluminescence immunoassay | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2016) 59: 2328-2342 [PMID:26812066] |
ChEMBL | Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated for 60 mins by HTRF assay | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2016) 59: 2328-2342 [PMID:26812066] |
CYP3A4 in Human [GtoPdb: 1337] [UniProtKB: P08684] | ||||||||
GtoPdb | - | - | 4.3 | pIC50 | 50000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6307-12 [PMID:19819693] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]