ChEMBL ligand: CHEMBL255738
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL	Mixed-type inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using abtide peptide as substrate	B	6.33	pKi	470	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of histidine-tagged human recombinant ABL T315I mutant expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using abtide peptide as substrate	B	6.35	pKi	450	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of histidine-tagged human recombinant ABL T315I mutant expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using ATP as substrate	B	6.4	pKi	400	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using abtide peptide as substrate	B	6.92	pKi	120	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using ATP as substrate	B	7	pKi	100	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of human recombinant Abl	B	7.36	pKi	44	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1207-1211 [PMID:18078752]
GtoPdb	-	-	7.36	pKi	44	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1207-11 [PMID:18078752]; Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of histidine-tagged human recombinant SRC expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using ATP as substrate	B	6.26	pKi	550	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of histidine-tagged human recombinant SRC expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using KVEKIGEGTYGVVYK as substrate	B	6.26	pKi	550	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of recombinant human c-Src	B	6.45	pKi	354	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1207-1211 [PMID:18078752]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]