Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL278020 (Miostin, Neostigmine, Neostigmine (cation), Neostigmine cation, Neostigmine hydroxide, Neostigmine ion) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
ChEMBL | Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate preincubated for 10 mins followed by substrate addition measured every 30 secs for 30 mins by Ellmans method | B | 8.34 | pIC50 | 4.6 | nM | IC50 | Medchemcomm (2011) 2: 406-412 |
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 4.55 | pIC50 | 28300 | nM | IC50 | Bioorg Med Chem (2014) 22: 6163-6173 [PMID:25257911] |
ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method | B | 4.66 | pIC50 | 22000 | nM | IC50 | Eur J Med Chem (2014) 78: 43-53 [PMID:24675179] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured after 15 mins by Ellman's method | B | 4.79 | pIC50 | 16300 | nM | IC50 | Eur J Med Chem (2019) 180: 656-672 [PMID:31352246] |
ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method | B | 4.85 | pIC50 | 14200 | nM | IC50 | Eur J Med Chem (2014) 78: 167-177 [PMID:24681981] |
ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 5.12 | pIC50 | 7500 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127505-127505 [PMID:32822761] |
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of AChE (unknown origin) using ACh chloride as substrate preincubated for 15 mins before substrate addition by Ellman method | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3618-3621 [PMID:24909082] |
GtoPdb | Inhibition of ACHE activity in human serum. | - | 7.35 | pIC50 | 45 | nM | IC50 | Bioorg Med Chem (2007) 15: 7391-8 [PMID:17888667] |
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
ChEMBL | Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method | B | 4.31 | pIC50 | 49100 | nM | IC50 | Eur J Med Chem (2014) 78: 43-53 [PMID:24675179] |
ChEMBL | Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method | B | 4.58 | pIC50 | 26100 | nM | IC50 | Eur J Med Chem (2014) 78: 167-177 [PMID:24681981] |
ChEMBL | Inhibition of human BChE by Ellman's method | B | 4.79 | pIC50 | 16300 | nM | IC50 | Bioorg Med Chem (2014) 22: 6163-6173 [PMID:25257911] |
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
ChEMBL | Inhibition of BuChE in equine serum using butyrylthiocholine chloride as substrate preincubated with enzyme for 10 mins prior to substrate challenge for 15 mins by Ellman's method | B | 4.3 | pIC50 | 49600 | nM | IC50 | Eur J Med Chem (2014) 78: 106-117 [PMID:24681070] |
ChEMBL | Inhibition of equine BuChE by Ellman's method | B | 5.53 | pIC50 | 2930 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127505-127505 [PMID:32822761] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]