brivaracetam [Ligand Id: 9041] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL607400 (Brivaracetam, Briviact, UCB 34714, UCB-34714) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| synaptic vesicle glycoprotein 2A/Synaptic vesicle protein 2a in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4381] [GtoPdb: 2634] [UniProtKB: Q02563] | ||||||||
| ChEMBL | Displacement of [3H]-2-[4-(3-azidophenyl)-2-oxo-1-pyrrolidinyl]butanamide from SV2A levetiracetam binding site in Sprague-Dawley rat cerebral cortex membranes after 120 mins by liquid scintillation counting method | B | 6 | pKi | <=1000 | nM | Ki | EP-1452524-A1. 2-oxo-1-pyrrolidine derivative and its pharmaceutical uses (2004) |
| GtoPdb | In vitro inhibitory activity against [3H](2S)-2-[4-(3-azidophenyl)-2-oxopyrrolidin-1-yl]butanamide binding to levetiracetam binding site, in rat brain homogenate. | - | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2004) 47: 530-49 [PMID:14736235] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
