ChEMBL ligand: CHEMBL500 (Apo-pindol, Betadren, Betapindol, Blocklin-l, Calvisken, Carvisken, Decreten, Dl-lb-46, Dl-pindolol, Durapindol, Glauco-visken, LB-46, NSC-757276, Pectobloc, Pinbetol, Pindolol, Prinodolol, Pynastin, (rs)-pindolol, Visken)
β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] There should be some charts here, you may need to enable JavaScript!
β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] There should be some charts here, you may need to enable JavaScript!
β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] There should be some charts here, you may need to enable JavaScript!
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Rat [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223] There should be some charts here, you may need to enable JavaScript!
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	F	5	pKd	<10000	nM	Kd	J Med Chem (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	Displacement of [3H]-CGP 12177 from human beta-1 adrenergic receptor expressed in CHOK1 cells	B	8.58	pKd	2.63	nM	Kd	J Med Chem (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	F	8.62	pKd	2.4	nM	Kd	J Med Chem (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol)	B	9.27	pKi	0.53	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Binding affinity at human adrenergic beta-1 receptor	B	9.28	pKi	0.52	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5600-5604 [PMID:17804228]
GtoPdb	-	-	9.3	pKi	-	-	-	Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599]; Bioorg Med Chem Lett (2007) 17: 5600-4 [PMID:17804228]
GtoPdb	-	-	9.7	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (2004) 369: 525-32 [PMID:15060759]; Mol Pharmacol (2003) 64: 1357-69 [PMID:14645666]; Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599]
ChEMBL	DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol)	B	9.04	pIC50	0.92	nM	IC50	DrugMatrix in vitro pharmacology data
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL	Antagonist activity at human beta-2 adrenergic receptor expressed in salbutamol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	F	9.18	pKd	0.66	nM	Kd	J Med Chem (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cells	B	9.27	pKd	0.54	nM	Kd	J Med Chem (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	Binding affinity at human adrenergic beta2 receptor	B	9.4	pKi	0.4	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5600-5604 [PMID:17804228]
GtoPdb	-	-	9.4	pKi	-	-	-	Bioorg Med Chem Lett (2007) 17: 5600-4 [PMID:17804228]
GtoPdb	-	-	9.4	pKi	0.4	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5600-4 [PMID:17804228]
ChEMBL	DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177)	B	9.42	pKi	0.38	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177)	B	9.26	pIC50	0.55	nM	IC50	DrugMatrix in vitro pharmacology data
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
ChEMBL	Antagonist activity at human beta-3 adrenergic receptor expressed in fenoterol-stimulated CHOK1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis	F	6	pKd	<1000	nM	Kd	J Med Chem (2011) 54: 6874-6887 [PMID:21870877]
ChEMBL	Displacement of [3H]-CGP 12177 from human beta-3 adrenergic receptor expressed in CHOK1 cells	B	6.78	pKd	165.96	nM	Kd	J Med Chem (2011) 54: 6874-6887 [PMID:21870877]
GtoPdb	-	-	7.1	pKi	-	-	-	Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599]
ChEMBL	DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)	B	7.18	pKi	66	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)	B	7.06	pIC50	88	nM	IC50	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	7.4	pEC50	-	-	-	Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Binding affinity to 5HT1A receptor	B	7.2	pKd	63.1	nM	Kd	J Med Chem (2009) 52: 6107-6125 [PMID:19754201]
ChEMBL	Inhibition constant against 5-hydroxytryptamine 1A receptor	B	6.96	pKi	110	nM	Ki	J Med Chem (2005) 48: 6523-6543 [PMID:16220969]
ChEMBL	Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S binding	F	7.09	pKi	81.1	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5600-5604 [PMID:17804228]
ChEMBL	Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells	B	7.62	pKi	24	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3243-3248 [PMID:10576696]
ChEMBL	Displacement of [3H]DPAT from human 5HT1A receptor	B	7.65	pKi	22.4	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5600-5604 [PMID:17804228]
GtoPdb	-	-	8.1	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 205-17 [PMID:9550290]
ChEMBL	Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells	B	7.57	pEC50	27	nM	EC50	Bioorg Med Chem Lett (1999) 9: 3243-3248 [PMID:10576696]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)	B	7.57	pKi	27	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement	B	7.66	pKi	21.88	nM	Ki	J Med Chem (1996) 39: 126-134 [PMID:8568799]
ChEMBL	Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a radioligand.	B	7.7	pKi	20	nM	Ki	J Med Chem (1987) 30: 1-12 [PMID:3543362]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)	B	7.32	pIC50	48	nM	IC50	DrugMatrix in vitro pharmacology data
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL	Agonist activity to the human recombinant 5-hydroxytryptamine 1B receptor	F	5	pKi	>10000	nM	Ki	J Med Chem (1997) 40: 4415-4419 [PMID:9435911]
ChEMBL	Agonist activity to the human recombinant 5-hydroxytryptamine 1B receptor	F	5.59	pKi	2600	nM	Ki	J Med Chem (1997) 40: 4415-4419 [PMID:9435911]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL	Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand.	B	7.1	pKi	80	nM	Ki	J Med Chem (1987) 30: 1-12 [PMID:3543362]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL	Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand.	B	4.27	pKi	54000	nM	Ki	J Med Chem (1987) 30: 1-12 [PMID:3543362]
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL	Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortex	B	5.15	pKi	>7000	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3243-3248 [PMID:10576696]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb	-	-	5	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]
GtoPdb	-	-	5	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
GtoPdb	-	-	5.7	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]
GtoPdb	-	-	5.7	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]