periciazine [Ligand Id: 9216] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL251940 (Neulactil, NSC-758641, Periciazine, Pericyazine, Propericiazine, RP 8909, RP-8909, SKF 20716, SKF-20716) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795] | ||||||||
| ChEMBL | Inhibition of bovine erythrocyte AChE using acetylthiocholine iodide as a substrate after 20 mins by Ellman's assay | B | 5.15 | pIC50 | 7000 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] | ||||||||
| ChEMBL | Displacement of [3H]mibolerone from rat androgen receptor | B | 5.52 | pKi | 3000 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 11927-11932 [PMID:17606915] |
| Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
| ChEMBL | Inhibition of Equine serum BChE using butyrylthiocholine iodide as a substrate after 20 mins by Ellman's assay | B | 6.64 | pIC50 | 230 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay | F | 5.18 | pIC50 | 6562 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3597-3604 [PMID:20547797] |
| D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| GtoPdb | - | - | 8 | pKi | 10 | nM | Ki | J Psychiatry Neurosci (1994) 19: 265-9 [PMID:7918347] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
