compound 4g [PMID: 22220592] [Ligand Id: 9236] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2024115 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| ChEMBL | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting | B | 7.07 | pKi | 85.11 | nM | Ki | J Med Chem (2012) 55: 1898-1903 [PMID:22220592] |
| A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| ChEMBL | Binding affinity to adenosine A2A receptor by surface plasmon resonance | B | 8.9 | pKd | 1.26 | nM | Kd | J Med Chem (2012) 55: 1898-1903 [PMID:22220592] |
| GtoPdb | - | - | 8.11 | pKi | 7.76 | nM | Ki | J Med Chem (2012) 55: 1898-903 [PMID:22220592] |
| ChEMBL | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting | B | 8.11 | pKi | 7.76 | nM | Ki | J Med Chem (2012) 55: 1898-1903 [PMID:22220592] |
| A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| ChEMBL | Inhibition of adenosine A2B receptor | B | 7.3 | pKi | 50.12 | nM | Ki | J Med Chem (2012) 55: 1898-1903 [PMID:22220592] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
