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ChEMBL ligand: CHEMBL3358920 (Apd334, APD-334, APD334, APD-334(FREE ACID), Etrasimod) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
ChEMBL | Binding affinity to human adenosine A3 receptor | B | 5.48 | pIC50 | 3300 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG by patch clamp assay | B | 4.52 | pIC50 | >30000 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
ChEMBL | Displacement of [3H]astemizole from human ERG | B | 4.52 | pIC50 | >30000 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
Sphingosine 1-phosphate receptor 1 in Rhesus macaque (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559675] [UniProtKB: H9EUW9] | ||||||||
ChEMBL | Agonist activity at monkey S1P1 receptor assessed as cAMP accumulation by HTRF assay | F | 9.49 | pEC50 | 0.32 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
S1P1 receptor in Human [GtoPdb: 275] [UniProtKB: P21453] | ||||||||
GtoPdb | In a β-arrestin recruitment assay. | - | 8.21 | pEC50 | 6.1 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-7 [PMID:25516790] |
GtoPdb | - | - | 9.24 | pEC50 | 0.57 | nM | EC50 | PLoS One (2019) 14: e0226154 [PMID:31805144] |
S1P1 receptor/Sphingosine 1-phosphate receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914262] [GtoPdb: 275] [UniProtKB: O08530] | ||||||||
ChEMBL | Agonist activity at mouse S1P1 receptor assessed as cAMP accumulation by HTRF assay | F | 9.36 | pEC50 | 0.44 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
S1P1 receptor/Sphingosine 1-phosphate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914263] [GtoPdb: 275] [UniProtKB: P48303] | ||||||||
ChEMBL | Agonist activity at rat S1P1 receptor assessed as cAMP accumulation by HTRF assay | F | 9.49 | pEC50 | 0.32 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
Sphingosine-1-phosphate receptor 1 in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559680] [UniProtKB: W5VNF7] | ||||||||
ChEMBL | Agonist activity at dog S1P1 receptor assessed as cAMP accumulation by HTRF assay | F | 9.47 | pEC50 | 0.34 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453] | ||||||||
ChEMBL | Induction of internalization of HA-tagged human S1P1 receptor expressed in CHO cells | B | 8.73 | pIC50 | 1.88 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
GtoPdb | In a β-arrestin recruitment assay. | - | 8.21 | pEC50 | 6.1 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-7 [PMID:25516790] |
ChEMBL | Agonist activity at human S1P1 receptor by beta-arrestin recruitment assay | B | 8.21 | pEC50 | 6.1 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
GtoPdb | - | - | 9.24 | pEC50 | 0.57 | nM | EC50 | PLoS One (2019) 14: e0226154 [PMID:31805144] |
ChEMBL | Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assay | F | 10.4 | pEC50 | 0.04 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500] | ||||||||
ChEMBL | Agonist activity at human S1P3 receptor by beta-arrestin recruitment assay | B | 5 | pEC50 | >10000 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
S1P2 receptor/Sphingosine 1-phosphate receptor Edg-5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2955] [GtoPdb: 276] [UniProtKB: O95136] | ||||||||
ChEMBL | Agonist activity at human S1P2 receptor by beta-arrestin recruitment assay | B | 5 | pEC50 | >10000 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977] | ||||||||
GtoPdb | In a β-arrestin recruitment assay. | - | 6.83 | pEC50 | 147 | nM | EC50 |
Br J Pharmacol (2002) 136: 847-56 [PMID:12110609]; ACS Med Chem Lett (2014) 5: 1313-7 [PMID:25516790] |
ChEMBL | Agonist activity at human S1P4 receptor by beta-arrestin recruitment assay | B | 6.83 | pEC50 | 147 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228] | ||||||||
GtoPdb | In a β-arrestin recruitment assay. | - | 7.61 | pEC50 | 24.4 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-7 [PMID:25516790] |
ChEMBL | Agonist activity at human S1P5 receptor by beta-arrestin recruitment assay | B | 7.61 | pEC50 | 24.4 | nM | EC50 | ACS Med Chem Lett (2014) 5: 1313-1317 [PMID:25516790] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]