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ChEMBL ligand: CHEMBL493076 (AC-55541) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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PAR2/Proteinase-activated receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5963] [GtoPdb: 348] [UniProtKB: P55085] | ||||||||
ChEMBL | Agonist activity at human PAR2 expressed in HEK293T cells assessed as increase in intracellular calcium level by bioluminescence assay | F | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (2013) 56: 7477-7497 [PMID:23895492] |
ChEMBL | Agonist activity at human PAR2 expressed in HEK293T cells assessed as stimulation of phosphatidylinositol hydrolysis after 45 mins by scintillation counting analysis | F | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (2013) 56: 7477-7497 [PMID:23895492] |
ChEMBL | Agonist activity at human PAR2 expressed in HEK293T cells assessed as stimulation of cell proliferation after 5 days by beta-galactosidase assay | B | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (2013) 56: 7477-7497 [PMID:23895492] |
ChEMBL | Agonist activity at human PAR2 expressed in HEK293T cells assessed as effect on intracellular calcium mobilization by R-SAT assay | F | 6.7 | pEC50 | 199.53 | nM | EC50 | J Med Chem (2008) 51: 5490-5493 [PMID:18720984] |
GtoPdb | - | - | 6.7 | pEC50 | 199 | nM | EC50 | J Med Chem (2008) 51: 5490-3 [PMID:18720984] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]