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ChEMBL ligand: CHEMBL771 (Cycloserine, Cycloserinum, D-cycloserine, NSC-154851, NSC-76029, Orientomycin, Seromycin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
ChEMBL | In vitro inhibition of [3H]glycine at NMDA receptor | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (1994) 37: 4053-4067 [PMID:7990104] |
ChEMBL | In vitro concentration eliciting half-maximal effect on [3H]-MK 801 radioligand binding to NMDA receptor | B | 5.53 | pEC50 | 2950 | nM | EC50 | Bioorg Med Chem Lett (1999) 9: 1409-1414 [PMID:10360746] |
GluN2C/Glutamate [NMDA] receptor subunit epsilon 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL401] [GtoPdb: 458] [UniProtKB: Q00961] | ||||||||
ChEMBL | Compound was evaluated for in vitro inhibition of [3H]TCP at NMDA receptor. | B | 4.74 | pEC50 | 18100 | nM | EC50 | J Med Chem (1994) 37: 4053-4067 [PMID:7990104] |
GluN1/Glutamate (NMDA) receptor subunit zeta 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL330] [GtoPdb: 455] [UniProtKB: P35439] | ||||||||
ChEMBL | In vitro inhibitory activity to inhibit [3H]glycine binding to NMDA receptor | B | 5.13 | pIC50 | 7370 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 1409-1414 [PMID:10360746] |
Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8] | ||||||||
ChEMBL | Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting | B | 0.64 | pKi | -0.64 | mM | pKi | Bioorg Med Chem (2011) 19: 6409-6418 [PMID:21955456] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]