ChEMBL ligand: CHEMBL267044 (Lesuride, Levobren, Levopraid, Levopride, Levosulpiride, L-sulpiride, S-(-)-sulpiride, (-)-sulpiride, Sulpiride, (-)-, Sulpiride l-form, Sulpiride, (s)-)
Dopamine D1 receptor in Bovine [ChEMBL: CHEMBL2967] [UniProtKB: Q95136] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] There should be some charts here, you may need to enable JavaScript!
myeloperoxidase/Myeloperoxidase in Human [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Dopamine D1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2967] [UniProtKB: Q95136]
ChEMBL	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2000) 10: 2041-2044 [PMID:10987445]
ChEMBL	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (1999) 9: 841-846 [PMID:10206547]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D2L stably expressed in CHO cells	B	6.92	pKi	120	nM	Ki	Bioorg Med Chem Lett (2000) 10: 2041-2044 [PMID:10987445]
ChEMBL	Binding affinity towards human Dopamine receptor D2 (long) by [3H]-spiperone displacement.	B	6.92	pKi	120	nM	Ki	Bioorg Med Chem Lett (1999) 9: 841-846 [PMID:10206547]
ChEMBL	In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D2 short form expressed in CHO cells	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem Lett (2000) 10: 2041-2044 [PMID:10987445]
ChEMBL	Binding affinity towards human Dopamine receptor D2 (short) by [3H]-spiperone displacement.	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem Lett (1999) 9: 841-846 [PMID:10206547]
ChEMBL	DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)	B	7.37	pKi	43	nM	Ki	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	8	pKi	10	nM	Ki	J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582]; Eur J Pharmacol (1992) 225: 331-7 [PMID:1354163]; J Pharmacol Exp Ther (1994) 268: 495-502 [PMID:8301592]
ChEMBL	DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)	B	6.89	pIC50	128	nM	IC50	DrugMatrix in vitro pharmacology data
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat	B	7.41	pKi	39	nM	Ki	J Med Chem (1987) 30: 2099-2104 [PMID:2889830]
ChEMBL	Compound was evaluated for binding affinity towards DA D-2 receptor using radioligand [3H]SPI	B	7.41	pKi	39	nM	Ki	J Med Chem (1992) 35: 2355-2363 [PMID:1535660]
ChEMBL	Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.	B	7.54	pKi	29	nM	Ki	J Med Chem (1991) 34: 261-267 [PMID:1825115]
ChEMBL	Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum	B	7.69	pKi	20.6	nM	Ki	J Med Chem (1992) 35: 552-558 [PMID:1346653]
ChEMBL	Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2	B	8.16	pKi	6.9	nM	Ki	J Med Chem (1990) 33: 1155-1163 [PMID:1969484]
ChEMBL	Inhibitory concentration required for displacing radioligand [3H]SPI from DA D-2 receptor	F	6.63	pIC50	233	nM	IC50	J Med Chem (1992) 35: 2355-2363 [PMID:1535660]
ChEMBL	In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.	B	6.68	pIC50	210	nM	IC50	J Med Chem (1990) 33: 1155-1163 [PMID:1969484]
ChEMBL	Inhibitory concentration required for displacing radioligand [3H]SPI from DA D-2 receptor	B	6.77	pIC50	170	nM	IC50	J Med Chem (1992) 35: 2355-2363 [PMID:1535660]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL	In vitro displacement of [3H]spiperone from the cloned human dopamine receptor D3 stably expressed in CHO cells	B	7.06	pKi	88	nM	Ki	Bioorg Med Chem Lett (2000) 10: 2041-2044 [PMID:10987445]
ChEMBL	Binding affinity towards human dopamine D3 receptor by [3H]spiperone displacement.	B	7.06	pKi	88	nM	Ki	Bioorg Med Chem Lett (1999) 9: 841-846 [PMID:10206547]
ChEMBL	DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)	B	7.38	pKi	42	nM	Ki	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	7.7	pKi	20	nM	Ki	J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582]; Eur J Pharmacol (1992) 225: 331-7 [PMID:1354163]; J Pharmacol Exp Ther (1994) 268: 495-502 [PMID:8301592]
ChEMBL	DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)	B	6.91	pIC50	123	nM	IC50	DrugMatrix in vitro pharmacology data
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL	In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D4 expressed in CHO cells	B	5.68	pKi	2100	nM	Ki	Bioorg Med Chem Lett (2000) 10: 2041-2044 [PMID:10987445]
ChEMBL	Binding affinity towards human Dopamine receptor D4 by [3H]spiperone displacement.	B	5.68	pKi	2100	nM	Ki	Bioorg Med Chem Lett (1999) 9: 841-846 [PMID:10206547]
GtoPdb	-	-	7.7	pKi	20	nM	Ki	J Pharmacol Exp Ther (1994) 268: 495-502 [PMID:8301592]; Mol Pharmacol (1996) 50: 1658-64 [PMID:8967990]
myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164]
ChEMBL	Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed by H2O2 addition measured after 5 mins	B	5.11	pIC50	7680	nM	IC50	J Med Chem (2017) 60: 6563-6586 [PMID:28671460]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampus	B	6	pKi	>1000	nM	Ki	J Med Chem (1992) 35: 552-558 [PMID:1346653]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]