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ChEMBL ligand: CHEMBL432798 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG expressed in HEK293 cells by patch clamp method | B | 4.54 | pIC50 | 28600 | nM | IC50 | J Med Chem (2017) 60: 5290-5305 [PMID:28613871] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
GtoPdb | In vitro determination. | - | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2017) 60: 5290-5305 [PMID:28613871] |
ChEMBL | Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assay | B | 6.73 | pIC50 | 188 | nM | IC50 | J Med Chem (2011) 54: 3283-3297 [PMID:21449619] |
phosphodiesterase 4B in Human [GtoPdb: 1301] [UniProtKB: Q07343] | ||||||||
GtoPdb | Determined against the PDE4B1 splice variant. | - | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (2017) 60: 5290-5305 [PMID:28613871] |
phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499] | ||||||||
GtoPdb | Determined against the PDE4D3 splice variant. | - | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2017) 60: 5290-5305 [PMID:28613871] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]