ASN002

Ligand id: 10000

Name: ASN002

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 120.65
Molecular weight 461.23
XLogP 0.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[1-(4-{[4-(4-hydroxypiperazin-1-yl)phenyl]amino}-5-oxo-5H,6H-pyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl]acetonitrile
Comments
ASN002 is an orally bioavailable dual spleen tyrosine kinase (SYK)/Janus kinase (JAK) inhibitor that is being developed by Ascena Biopharmaceuticals. It is being evaluated for clinical efficacy in inflammatory and oncology settings. The chemical structure shown here was obtained from Bryan and Rajapaksa (2018) [1].
Database Links
GtoPdb PubChem SID 374883887
PubChem CID 134611897
Search Google for chemical match using the InChIKey POAZPIKWEFFCBP-UHFFFAOYSA-N
Search Google for chemicals with the same backbone POAZPIKWEFFCBP
Search UniChem for chemical match using the InChIKey POAZPIKWEFFCBP-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone POAZPIKWEFFCBP