ASN002

Ligand id: 10000

Name: ASN002

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 134.06
Molecular weight 460.23
XLogP 2.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
example 189 [WO2013028818A1] | gusacitinib (proposed INN)
Comments
ASN002 is an orally bioavailable dual spleen tyrosine kinase (SYK)/pan Janus kinase (JAK) inhibitor that is being developed by Asana BioSciences. It is being evaluated for clinical efficacy in inflammatory and oncology settings. The chemical structure shown here matches the IUPAC name and CAS number submitted to the WHO for the INN gusacitinib. Not to be confused with Ascend Biopharmaceuticals immuno-oncology lead ASN-002, which is an engineered virus that expresses IFN-γ.
ASN002 is one of the chemical structures (example 189) claimed in Asana Biosciences' patent WO2013028818A1 [2].
Database Links
GtoPdb PubChem SID 374883887
PubChem CID 71269142
Search Google for chemical match using the InChIKey NLFLXLJXEIUQDL-UHFFFAOYSA-N
Search Google for chemicals with the same backbone NLFLXLJXEIUQDL
Search UniChem for chemical match using the InChIKey NLFLXLJXEIUQDL-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone NLFLXLJXEIUQDL