Compound 9 [doi:10.26434/chemrxiv.7072592.v1]

Ligand id: 10083

Name: Compound 9 [doi:10.26434/chemrxiv.7072592.v1]

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Synthetic organic
Comments
The compound (from a pre-print) is selective KDM5 covalent inhibitor designed to target cysteine residues only present in the KDM5 sub-family [1]. Target engagement and ChIP-seq analysis showed that compound 7 inhibited KDM5B in cells and induced a global increase of the H3K4me3 mark at transcriptional start sites. KDM5B is thus involved in the epigenetic regulatory pathway of immune response and potential targets for antipathogen and anticancer immunotherapy.
Database Links
GtoPdb PubChem SID 375973270
Search Google for chemical match using the InChIKey GAWCCMHWAMQURK-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GAWCCMHWAMQURK
Search UniChem for chemical match using the InChIKey GAWCCMHWAMQURK-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone GAWCCMHWAMQURK