H-151

Ligand id: 10122

Name: H-151

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 56.92
Molecular weight 279.14
XLogP 3.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-(4-ethylphenyl)-1-(1H-indol-3-yl)urea
Synonyms
H 151 | H151
Comments
H-151 is a covalent STING antagonist [1]. Mechanistically it binds to Cys91 of the protein and prevents its palmitoylation. The non-modified STING protein is then unable to assemble the STING complexes that are essential to activate downstream processes.
Database Links
CAS Registry No. 941987-60-6 (source: PubChem)
GtoPdb PubChem SID 381118832
PubChem CID 7616033
Search Google for chemical match using the InChIKey UJZDIKVQFMCLBE-UHFFFAOYSA-N
Search Google for chemicals with the same backbone UJZDIKVQFMCLBE
Search UniChem for chemical match using the InChIKey UJZDIKVQFMCLBE-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone UJZDIKVQFMCLBE

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Tocris
H 151
Cat. No. 6675