NFP

Ligand id: 10185

Name: NFP

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 94.92
Molecular weight 465.21
XLogP 1.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(3'-fluoro-4'-pyridyl)acetamido]morphinan
Synonyms
compound 1 [PMID: 30608693]
Comments
NFP is a μ/κ opioid receptor dual selective antagonist. It is able to cross the blood-brain barrier so acts both centrally and peripherally [1]. In vivo evidence suggests NFP as a lead compound in the search for new agents to treat opioid abuse and addiction.
Database Links
GtoPdb PubChem SID 381118895
Search Google for chemical match using the InChIKey JRUPWWCGTBJDNY-LNMFUWNLSA-N
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Search UniChem for chemical match using the InChIKey JRUPWWCGTBJDNY-LNMFUWNLSA-N
Search UniChem for chemicals with the same backbone JRUPWWCGTBJDNY