volociximab

Ligand id: 10236

Name: volociximab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
8600 volociximab
Synonyms
M200
Comments
Volociximab is a chimeric human IgG4 anti-integrin α5 subunit monoclonal antibody [5]. It blocks the interaction between α5β1 and fibronectin and inhibits the complex's functional activity [4], and was originally developed for anti-angiogenic, anti-tumour potential [1-2]. Volociximab does not cross-react with murine α5β1 so is unsuitable for use in standard xenograft models [2]. A rat anti-mouse function-blocking α5β1 designed for murine experiments has been reported (339.1, Kd 0.59 nM), and like volociximab it inhibits angiogenesis and slows tumour growth in vivo[3].
Database Links
Specialist databases
IMGT/mAb-DB 256
Other databases
GtoPdb PubChem SID 381744918
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