Synonyms: ITZ | R-51211 | R51211 | Sporanox®
itraconazole is an approved drug (FDA (1992), UK (1989))
Compound class:
Synthetic organic
Comment: Itraconazole is an antimycotic drug. It inhibits fungal cytochrome P450 enzymes. It has been reported to exhibit antiviral activity towards SARS-CoV-2 (in VERO-E6 cells), potentially via inhibition of the virus' main protease (M-Pro, 3CL-Pro).
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Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (FDA (1992), UK (1989)) |
WHO Essential Medicine | WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version. Click to view more information about the WHO Model Lists of Essential Medicines. |
IUPAC Name |
2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one |
International Nonproprietary Names | |
INN number | INN |
5387 | itraconazole |
Synonyms |
ITZ | R-51211 | R51211 | Sporanox® |
Database Links | |
BindingDB Ligand | 50127138 |
CAS Registry No. | 84625-61-6 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL22587 |
DrugBank Ligand | DB01167 |
GtoPdb PubChem SID | 440816795 |
PubChem CID | 55283 |
Search Google for chemical match using the InChIKey | VHVPQPYKVGDNFY-ZPGVKDDISA-N |
Search Google for chemicals with the same backbone | VHVPQPYKVGDNFY |
Search PubMed clinical trials | itraconazole |
Search PubMed titles | itraconazole |
Search PubMed titles/abstracts | itraconazole |
UniChem Compound Search for chemical match using the InChIKey | VHVPQPYKVGDNFY-ZPGVKDDISA-N |
UniChem Connectivity Search for chemical match using the InChIKey | VHVPQPYKVGDNFY-ZPGVKDDISA-N |