urotensin II-related peptide   Click here for help

GtoPdb Ligand ID: 2156

Abbreviated name: URP
Synonyms: urotensin-related peptide
Compound class: Endogenous peptide in human, mouse or rat
Species: Human, Mouse, Rat
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES NCCCCC1NC(=O)C(NC(=O)C(CC2CCCCC2)NC(=O)C(CSSCC(NC(=O)C(NC1=O)Cc1ccc(cc1)O)C(=O)NC(C(=O)O)C(C)C)NC(=O)C(N)C)Cc1c[nH]c2c1cccc2
Isomeric SMILES NCCCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC1=O)Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)O)C(C)C)NC(=O)[C@@H](N)C)Cc1c[nH]c2c1cccc2
InChI InChI=1S/C49H70N10O10S2/c1-27(2)41(49(68)69)59-48(67)40-26-71-70-25-39(57-42(61)28(3)51)47(66)55-36(21-29-11-5-4-6-12-29)44(63)56-38(23-31-24-52-34-14-8-7-13-33(31)34)46(65)53-35(15-9-10-20-50)43(62)54-37(45(64)58-40)22-30-16-18-32(60)19-17-30/h7-8,13-14,16-19,24,27-29,35-41,52,60H,4-6,9-12,15,20-23,25-26,50-51H2,1-3H3,(H,53,65)(H,54,62)(H,55,66)(H,56,63)(H,57,61)(H,58,64)(H,59,67)(H,68,69)/t28-,35-,36-,37-,38-,39-,40-,41-/m0/s1
InChI Key BKBNRUZZGBUWOM-KOOAXUMWSA-N
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
IUPAC Name Click here for help
(2S)-2-[[(4R,7S,10S,13S,16S,19R)-10-(4-aminobutyl)-19-[[(2S)-2-aminopropanoyl]amino]-16-(cyclohexylmethyl)-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid
Synonyms Click here for help
urotensin-related peptide
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
UTS2B urotensin 2B Human prepro-URP U2B, urotensin 2 domain containing, URP, UTS2D
Uts2b urotensin 2B Mouse prepro-URP urotensin 2 domain containing, Urp, Uts2d
Uts2b urotensin 2B Rat prepro-URP U2B, U-IIB, UIIB, urotensin-2B, urotensin 2 domain containing, urotensin 2 domain-containing protein, urotensin-2 domain-containing protein, urotensin IIB, urotensin-IIB, urotensin II-related peptide, Urp, Uts2d
Database Links Click here for help
Specialist databases
GPCRdb Ligand urotensin II-related peptide
Other databases
CAS Registry No. 342878-90-4 (Hs)
ChEMBL Ligand CHEMBL437110
Ensembl Gene ENSG00000188958 (Hs), ENSRNOG00000038512 (Rn), ENSMUSG00000056423 (Mm)
Entrez Gene 224065 (Mm), 257313 (Hs), 378939 (Rn)
GtoPdb PubChem SID 135651910
Human Protein Atlas ENSG00000188958 (Hs)
PubChem CID 11995575
Search Google for chemical match using the InChIKey BKBNRUZZGBUWOM-KOOAXUMWSA-N
Search Google for chemicals with the same backbone BKBNRUZZGBUWOM
UniChem Compound Search for chemical match using the InChIKey BKBNRUZZGBUWOM-KOOAXUMWSA-N
UniChem Connectivity Search for chemical match using the InChIKey BKBNRUZZGBUWOM-KOOAXUMWSA-N
UniProtKB Q765I2 (Rn), Q765I1 (Mm), Q765I0 (Hs)