amantidine

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Ligands
amantidine

Ligand id: 4128

Name: amantidine

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	1
Hydrogen bond donors	1
Rotatable bonds	0
Topological polar surface area	26.02
Molecular weight	151.14
XLogP	2.31
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic
Approved drug?	Yes (source: FDA (1966))

IUPAC Name
adamantan-1-amine

IUPAC Name

adamantan-1-amine

International Nonproprietary Names
INN number	INN
1816	amantadine

Synonyms
Symadine®

Synonyms

Symadine®

Database Links
CAS Registry No.	768-94-5 (source: Scifinder)
ChEBI	CHEBI:2618
ChEMBL Ligand	CHEMBL660
DrugBank Ligand	DB00915
PubChem CID	2130
Search Google for chemical match using the InChIKey	DKNWSYNQZKUICI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone	DKNWSYNQZKUICI
Search PubMed clinical trials	amantadine
Search PubMed titles	amantadine
Search PubMed titles/abstracts	amantadine
Wikipedia	Amantidine

Comments
Chemically amantidine has an adamantane backbone with an amino group substituted at one of the four methyne positions. Clinically it has antiviral (blocking the viral M2 proton channel) and antiparkinsonian actions.

Comments

Chemically amantidine has an adamantane backbone with an amino group substituted at one of the four methyne positions. Clinically it has antiviral (blocking the viral M2 proton channel) and antiparkinsonian actions.