erythropoietin

Ligand id: 4921

Name: erythropoietin

Species: Human

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Classification
Compound class Endogenous peptide in human, mouse or rat
Approved drug? Yes (FDA (no history prior to 1989 available))
International Nonproprietary Names
INN number INN
6384 epoetin alfa
Synonyms
Epogen® | Procrit®
Comments
Recombinant forms of human erythropoietin (epoetins), are contained in various approved drugs with INNs that reflect the different glycoform structures formed by different manufacturing processes. The table below provides details of the epoetin alpha originator drug and biosimilars that are currently approved for use by the US FDA and/or the European Medicines Agency (EMA).

Epoetin alpha and biosimilar drugs.

INNTrade names (authorisation holder)First FDA approvalFirst EMA approval
epoetin alfaBinocrit (Sandoz), Abseamed (Medice Arzneimittel Pütter), Epogen (Amgen), Procrit (Janssen)19892007
epoetin betaNeoRecormon, Recormon (both Roche)n/a1997
epoetin zeta (a.k.a. epoetin alfa-epbx)Silapo (Stada Arzneimitte), Retacrit (Hospira)20182007
epoetin thetaBiopoin (Teva), Eporatio (Ratiopharm)n/a2009
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
EPO erythropoietin Human prepro-erythropoietin EP
Database Links
ChEMBL Ligand CHEMBL1201565
DrugBank Ligand DB00016
Ensembl Gene ENSG00000130427 (Hs)
GtoPdb PubChem SID 178101620
Human Protein Atlas ENSG00000130427 (Hs)
Search PubMed clinical trials epoetin alfa
Search PubMed titles epoetin alfa
Search PubMed titles/abstracts epoetin alfa
UniProtKB P01588 (Hs)
Wikipedia Epoetin alfa, Erythropoietin