NGF

Ligand id: 5026

Name: NGF

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Approved drug? Yes (EMA (2017), FDA (2018))
International Nonproprietary Names
INN number INN
10381 cenegermin
Synonyms
beta-nerve growth factor | beta-NGF | Oxervate® | Sentinel®
Comments
Recombinant NGF (cenegermin, also known as cenegermin-bkbj) is used clinically as a peripherally selective agonist of TrkA and LNGFR. Note that the recombinant peptide is two amino acids shorter than the endogenous peptide, with the carboxy-terminal RA (Arg-Ala) removed.
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
NGF nerve growth factor Human prepro-beta-nerve growth factor nerve growth factor (beta polypeptide), NGFB
Database Links
CATH/Gene3D 2.10.90.10
Ensembl Gene ENSG00000134259 (Hs)
GtoPdb PubChem SID 178101723
Human Protein Atlas ENSG00000134259 (Hs)
Search PubMed clinical trials cenegermin
Search PubMed titles cenegermin
Search PubMed titles/abstracts cenegermin
UniProtKB P01138 (Hs)
Wikipedia Nerve_growth_factor