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benserazide   Click here for help

GtoPdb Ligand ID: 5150

Synonyms: Madopar® | Ro 4-4602 | serazide
Approved drug
benserazide is an approved drug
Compound class: Synthetic organic
Comment: Marketed formulations may contain benserazide hydrochloride (PubChem CID 26964).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: benserazide

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 7
Rotatable bonds 6
Topological polar surface area 148.07
Molecular weight 257.1
XLogP -0.11
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OCC(C(=O)NNCc1ccc(c(c1O)O)O)N
Isomeric SMILES OCC(C(=O)NNCc1ccc(c(c1O)O)O)N
InChI InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18)
InChI Key BNQDCRGUHNALGH-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes.
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide
International Nonproprietary Names Click here for help
INN number INN
3026 benserazide
Synonyms Click here for help
Madopar® | Ro 4-4602 | serazide
Database Links Click here for help
CAS Registry No. 322-35-0
ChEBI CHEBI:64187
ChEMBL Ligand CHEMBL1096979
DrugCentral Ligand 314
GtoPdb PubChem SID 178101842
PubChem CID 2327
Search Google for chemical match using the InChIKey BNQDCRGUHNALGH-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BNQDCRGUHNALGH
Search PubMed clinical trials benserazide
Search PubMed titles benserazide
Search PubMed titles/abstracts benserazide
UniChem Compound Search for chemical match using the InChIKey BNQDCRGUHNALGH-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey BNQDCRGUHNALGH-UHFFFAOYSA-N
Wikipedia Benserazide