5-LOX activating protein

Ligand id: 5183

Name: 5-LOX activating protein

Abbreviated name: FLAP

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Synonyms
5-lipoxygenase-activating protein | arachidonate 5-lipoxygenase-activating protein
Comments
FLAP is a scaffolding protein involved in leukotriene (eicosanoid proinflammatory mediator) biosynthesis. It has been investigated as a molecular target for novel anti-inflammatory drugs [1,3], in particular for airway inflammation [2,4].
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
ALOX5AP arachidonate 5-lipoxygenase activating protein Human prepro-arachidonate 5-lipoxygenase-activating protein arachidonate 5-lipoxygenase-activating protein, five-lipoxygenase activating protein, FLAP, MK-886-binding protein
Database Links
CATH/Gene3D 1.20.120.550
Ensembl Gene ENSG00000132965 (Hs)
GtoPdb PubChem SID 178101873
Human Protein Atlas ENSG00000132965 (Hs)
UniProtKB P20292 (Hs)
Wikipedia 5-lipoxygenase_activating_protein