masitinib

Ligand id: 5656

Name: masitinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 101.63
Molecular weight 498.22
XLogP 4.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide
International Nonproprietary Names
INN number INN
8779 masitinib
Synonyms
AB-1010 | AB1010 | Masican® (proposed trade name)
Comments
Using the trade name Masivet, this compound has been used for several years to treat mast cell tumours in dogs [5]. It is a receptor tyrosine kinase (RTK) inhibitor, with inhibitory activity at the cKIT, platelet derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR) RTKs [3].
Database Links
CAS Registry No. 790299-79-5
ChEMBL Ligand CHEMBL1908391
GtoPdb PubChem SID 178102284
PubChem CID 10074640
RCSB PDB Ligand G65
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