foretinib

Ligand id: 5679

Name: foretinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 14
Topological polar surface area 111.25
Molecular weight 632.24
XLogP 5.56
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-N'-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinolin-4-yl}oxy)phenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
International Nonproprietary Names
INN number INN
9202 foretinib
Synonyms
EXEL-2880 | GSK 1363089G | GSK1363089 | XL 880
Database Links
CAS Registry No. 849217-64-7
ChEMBL Ligand CHEMBL1230609
PubChem CID 42642645
RCSB PDB Ligand 88Z
Search Google for chemical match using the InChIKey CXQHYVUVSFXTMY-UHFFFAOYSA-N
Search Google for chemicals with the same backbone CXQHYVUVSFXTMY
Search PubMed clinical trials foretinib
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Search UniChem for chemical match using the InChIKey CXQHYVUVSFXTMY-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone CXQHYVUVSFXTMY
SynPHARM 81202 (in complex with MET proto-oncogene, receptor tyrosine kinase)
79050 (in complex with MET proto-oncogene, receptor tyrosine kinase)
Wikipedia Foretinib
Comments
Foretinib is a small molecule ATP-competitive inhibitor principally of the protein kinases c-Met (HGFR) and vascular endothelial growth factor receptor 2 (VEGFR2, aka KDR) [4].