JNJ-28312141

Ligand id: 5689

Name: JNJ-28312141

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 105.12
Molecular weight 460.26
XLogP 2.75
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-cyano-N-[2-(cyclohex-1-en-1-yl)-4-{1-[2-(dimethylamino)acetyl]piperidin-4-yl}phenyl]-1H-imidazole-2-carboxamide
Synonyms
JNJ 28312141
Database Links
CAS Registry No. 885692-52-4
ChEMBL Ligand CHEMBL1908842
PubChem CID 11676971
Search Google for chemical match using the InChIKey GUBJNPWVIUFSTR-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GUBJNPWVIUFSTR
Search UniChem for chemical match using the InChIKey GUBJNPWVIUFSTR-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone GUBJNPWVIUFSTR
Comments
JNJ-28312141 is an inhibitor of the receptor tyrosine kinase, colony stimulating factor 1 receptor (CSF1R or FMS) and inhibits only five other tested kinases with an IC50 of <100nM [2]. CSF1R inhibitors are considered to have therapeutic potential for the prevention of osteolytic disease associated with bone metastasis and other bone diseases.