Ki-20227

Ligand id: 5690

Name: Ki-20227

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 132.07
Molecular weight 480.15
XLogP 3.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-2-methoxyphenyl}-3-[1-(1,3-thiazol-2-yl)ethyl]urea
Synonyms
Ki 20227 | Ki20227
Database Links
CAS Registry No. 623142-96-1
ChEMBL Ligand CHEMBL1908396
PubChem CID 9869779
Search Google for chemical match using the InChIKey SHPFDGWALWEPGS-UHFFFAOYSA-N
Search Google for chemicals with the same backbone SHPFDGWALWEPGS
Search UniChem for chemical match using the InChIKey SHPFDGWALWEPGS-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone SHPFDGWALWEPGS
Comments
Ki-20227 is an inhibitor of the receptor tyrosine kinase, colony stimulating factor 1 receptor (CSF1R or FMS) [2]. CSF1R inhibitors are considered to have therapeutic potential for the prevention of osteolytic disease associated with bone metastasis and other bone diseases.