GSK-3beta inhibitor I

Ligand id: 5977

Name: GSK-3beta inhibitor I

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 65.92
Molecular weight 222.05
XLogP 2.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK
Classification
Compound class Synthetic organic
IUPAC Name
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Synonyms
TDZD-8
Comments
Using the code TDZD-8, this compound is used as a reference compound in [5]. TDZD-8 is the first reported non-ATP competitive GSK-3β inhibitor [4], with positive effects on glucose homeostasis in obese mice [3]. It is a thiadiazolidinone type compound.
Database Links
CAS Registry No. 327036-89-5
ChEMBL Ligand CHEMBL284861
GtoPdb PubChem SID 178102600
PubChem CID 4124851
Search Google for chemical match using the InChIKey JDSJDASOXWCHPN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone JDSJDASOXWCHPN
Search UniChem for chemical match using the InChIKey JDSJDASOXWCHPN-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone JDSJDASOXWCHPN

Product suppliers

Tocris
TDZD 8
Cat. No. 6092