GSK-3beta inhibitor I

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Ligands
GSK-3beta inhibitor I

Ligand id: 5977

Name: GSK-3beta inhibitor I

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	4
Hydrogen bond donors	0
Rotatable bonds	2
Topological polar surface area	65.92
Molecular weight	222.05
XLogP	2.43
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic

IUPAC Name
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

IUPAC Name

4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Synonyms
TDZD-8

Synonyms

TDZD-8

Database Links
CAS Registry No.	327036-89-5
ChEMBL Ligand	CHEMBL284861
GtoPdb PubChem SID	178102600
PubChem CID	4124851
Search Google for chemical match using the InChIKey	JDSJDASOXWCHPN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone	JDSJDASOXWCHPN
Search UniChem for chemical match using the InChIKey	JDSJDASOXWCHPN-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone	JDSJDASOXWCHPN

Comments
Using the code TDZD-8, this compound is used as a reference compound in [5]. TDZD-8 is the first reported non-ATP competitive GSK-3β inhibitor [4], with positive effects on glucose homeostasis in obese mice [3]. It is a thiadiazolidinone type compound.

Comments

Using the code TDZD-8, this compound is used as a reference compound in [5]. TDZD-8 is the first reported non-ATP competitive GSK-3β inhibitor [4], with positive effects on glucose homeostasis in obese mice [3]. It is a thiadiazolidinone type compound.