PDK1/Akt/Flt dual pathway inhibitor

Ligand id: 6022

Name: PDK1/Akt/Flt dual pathway inhibitor

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 60.67
Molecular weight 224.04
XLogP 1.74
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
10,11,12,13,14,16-hexaazatetracyclo[7.7.0.0^{2,7}.0^{11,15}]hexadeca-1(16),2(7),3,5,9,12,14-heptaen-8-one
Synonyms
AG-L-66494 | GNF-Pf-3800
Database Links
CAS Registry No. 331253-86-2
ChEMBL Ligand CHEMBL599894
PubChem CID 5113385
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Comments
This compound is a mixture of tautomers (KP372-1A and KP372-1B), present in almost equal amounts. Our image shows the structure of KP372-1B.
This compound has been shown to directly inhibit both PDK1 and Akt activities in in vitro kinase assays in a dose-dependent manner and block cellular phosphorylation of Akt at both Ser473 and Thr308 residues [6].