GR 144053

Ligand id: 6587

Name: GR 144053

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 96.89
Molecular weight 345.22
XLogP -1.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[4-[4-(4-carbamimidoylphenyl)piperazin-1-yl]piperidin-1-yl]acetic acid
Synonyms
GR 144053 trihydrochloride | GR-144053 | GR144053
Database Links
CAS Registry No. 201304-22-5
ChEMBL Ligand CHEMBL36326
PubChem CID 173614
Search Google for chemical match using the InChIKey QGEGSJUSWLLZLH-UHFFFAOYSA-N
Search Google for chemicals with the same backbone QGEGSJUSWLLZLH
Search UniChem for chemical match using the InChIKey QGEGSJUSWLLZLH-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone QGEGSJUSWLLZLH
Comments
GR 144053 inhibits paltelet aggregation by binding to integrin αIIb/β3 [1], thereby preventing integrin binding to fibrinogen. The compound is orally actrive and long-acting.
Note that we show the parent molecule here, but the trihydrochloride salt may be used experimentally.