abatacept

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Ligands
abatacept

Ligand id: 6891

Name: abatacept

Summary
Biological activity
Clinical data
References
Structure
Immunopharmacology

Classification
Compound class	Antibody
Approved drug?	Yes (source: FDA (2005), EMA (2005))

International Nonproprietary Names
INN number	INN
8495	abatacept

Synonyms
BMS-188667
CTLA4-IgG4m
Orencia®
RG-1046
RG-2077

Synonyms

BMS-188667

CTLA4-IgG4m

Orencia®

RG-1046

RG-2077

Database Links
Specialist databases
IMGT/mAb-DB	212
Other databases
ChEMBL Ligand	CHEMBL1201823 (Hs)
DrugBank Ligand	DB01281
PubChem SID	135355129
Search PubMed clinical trials	abatacept
Search PubMed titles	abatacept
Search PubMed titles/abstracts	abatacept
Wikipedia	Abatacept

Comments
Abatacept is a recombinant protein fusing the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) [2]. In essence, abatacept is a CTLA-4 mimetic, that enhances CTLA-4's inhibitory signal to T cells, thereby down-modulating T cell mediated inflammation.

Comments

Abatacept is a recombinant protein fusing the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) [2]. In essence, abatacept is a CTLA-4 mimetic, that enhances CTLA-4's inhibitory signal to T cells, thereby down-modulating T cell mediated inflammation.