tideglusib

Ligand id: 6929

Name: tideglusib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 65.92
Molecular weight 334.08
XLogP 6.64
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
International Nonproprietary Names
INN number INN
9223 tideglusib
Synonyms
NP031112
Database Links
CAS Registry No. 865854-05-3 (source: Pub Chem)
PubChem CID 11313622
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Wikipedia Tideglusib
Comments
Tideglusib is a small molecule non-ATP-competitive, irreversible glycogen synthase kinase 3 (GSK-3β) inhibitor [2] that has been investigated as a potential treatment for Alzheimer's disease and paralysis supranuclear palsy [4]. Low-dose tideglusib has been reported to induce natural reparative dentine formation, as a novel approach to treating tooth decay [5].