TAK-070

Ligand id: 6940

Name: TAK-070

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 12.47
Molecular weight 385.24
XLogP 10.02
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N,N-dimethyl-2-[(2R)-6-[(4-phenylphenyl)methoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]ethanamine
Database Links
CAS Registry No. 212571-56-7 (source: Scifinder)
PubChem CID 10112962
Search Google for chemical match using the InChIKey SETMAZMOXYOEJA-NRFANRHFSA-N
Search Google for chemicals with the same backbone SETMAZMOXYOEJA
Search UniChem for chemical match using the InChIKey SETMAZMOXYOEJA-NRFANRHFSA-N
Search UniChem for chemicals with the same backbone SETMAZMOXYOEJA
Comments
TAK-070 from Takeda shows partial reduction in Aβ as well as increase in sAPPα in animal models. The noncompetitive BACE1 inhibition may be sufficient to modify amyloid pathology and ameliorate cognitive deficits in Alzheimer's Diseases without causing potential adverse events by complete BACE1 ablation.[1]