hydroxyzine

Ligand id: 7199

Name: hydroxyzine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 35.94
Molecular weight 374.18
XLogP 4.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1956))
IUPAC Name
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol
International Nonproprietary Names
INN number INN
599 hydroxyzine
Synonyms
Atarax® | hydroxyzine hydrochloride | hydroxyzine pamoate | Vistaril®
Database Links
CAS Registry No. 68-88-2
ChEMBL Ligand CHEMBL896
DrugBank Ligand DB00557
GtoPdb PubChem SID 178103774
PubChem CID 3658
Search Google for chemical match using the InChIKey ZQDWXGKKHFNSQK-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ZQDWXGKKHFNSQK
Search PubMed clinical trials hydroxyzine
Search PubMed titles hydroxyzine
Search PubMed titles/abstracts hydroxyzine
Search UniChem for chemical match using the InChIKey ZQDWXGKKHFNSQK-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ZQDWXGKKHFNSQK
Wikipedia Hydroxyzine
Comments
Hydroxyzine is a first-generation diphenylmethane and piperazine class antihistamine. Second-generation antihistamine cetirizine is one of the metabolites of hydroxyzine, but cetirizine differs in that it appears not to cross the blood-brain barrier to any significant level.