droxidopa

Ligand id: 7391

Name: droxidopa

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 5
Rotatable bonds 3
Topological polar surface area 124.01
Molecular weight 213.06
XLogP -3.14
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1024))
Is prodrug? Yes
Active form (-)-noradrenaline
IUPAC Name
(2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
International Nonproprietary Names
INN number INN
6120 droxidopa
Synonyms
L-DOPS | Northera® | SM-5688
Database Links
CAS Registry No. 23651-95-8 (source: SciFinder)
ChEMBL Ligand CHEMBL2103827
DrugBank Ligand DB06262
PubChem CID 92974
Search Google for chemical match using the InChIKey QXWYKJLNLSIPIN-JGVFFNPUSA-N
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Search UniChem for chemical match using the InChIKey QXWYKJLNLSIPIN-JGVFFNPUSA-N
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Wikipedia Droxidopa
Comments
As droxidopa is a prodrug for noradrenaline, its effects will be through noradrenaline activation of adrenoceptors. The cellular effect is dependent upon adrenoceptor subtype expression on target cells.