alpha1-proteinase inhibitor

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Ligands
alpha1-proteinase inhibitor

Ligand id: 7487

Name: alpha1-proteinase inhibitor

Summary
Biological activity
Clinical data
References
Structure

Classification
Compound class	Peptide or derivative
Approved drug?	Yes

Synonyms
A1AT
A1PI
alpha 1-antitrypsin
Aralast®
Prolastin®
serum trypsin inhibitor

Synonyms

A1AT

A1PI

alpha 1-antitrypsin

Aralast®

Prolastin®

serum trypsin inhibitor

Database Links
DrugBank Ligand	DB00058
Wikipedia	Alpha 1-antitrypsin

Comments
This is the human protein isolated and purified from donor plasma. There are 4 approved versions (Prolastin-C [7], Zemaira [6], Aralast [4] and Glassia [5]), which show minor chemical differences as a result of the methods used during purification [2]. PEGylated recombinant alpha-1-proteinase inhibitor has been tested [1,3], but no recombinant protein drug as been approved to date. US FDA approval dates: Prolastin-C (1987), Zemaira (2003), Aralast (2010) and Glassia (2010).

Comments

This is the human protein isolated and purified from donor plasma. There are 4 approved versions (Prolastin-C [7], Zemaira [6], Aralast [4] and Glassia [5]), which show minor chemical differences as a result of the methods used during purification [2]. PEGylated recombinant alpha-1-proteinase inhibitor has been tested [1,3], but no recombinant protein drug as been approved to date.
US FDA approval dates: Prolastin-C (1987), Zemaira (2003), Aralast (2010) and Glassia (2010).