2-PMAP

Ligand id: 7530

Name: 2-PMAP

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 45.15
Molecular weight 200.09
XLogP 2.89
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-(pyridin-2-ylmethylamino)phenol
Synonyms
AGN-PC-0031SD | ARN-2966
Database Links
CAS Registry No. 102212-26-0 (source: SciFinder)
PubChem CID 14936865
Search Google for chemical match using the InChIKey GXJRVWZNMZGWAQ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GXJRVWZNMZGWAQ
Search UniChem for chemical match using the InChIKey GXJRVWZNMZGWAQ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone GXJRVWZNMZGWAQ
Comments
2-PMAP is an investigational compound for Alzheimer's disease (AD). A recent study has demonstrated that this compound crosses the blood-brain barrier and reduces levels of full-length amyloid precursor protein (APP) and amyloid beta (Aβ) deposition in the brains of AD model mice without causing significant toxicity [1]. This is accompanied by reduced Aβ pathology and rescue of memory deficit in AD model mice via an inhibitory effect on mRNA translation. This compound may exist as a tautomer with PubChem CID 68604369.