cobicistat

Ligand id: 7535

Name: cobicistat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 3
Rotatable bonds 24
Topological polar surface area 194.5
Molecular weight 775.35
XLogP 8.36
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (source: FDA (2012))
IUPAC Name
1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
International Nonproprietary Names
INN number INN
9266 cobicistat
Synonyms
GS-9350
Database Links
CAS Registry No. 1004316-88-4
ChEBI CHEBI:72291
ChEMBL Ligand CHEMBL2095208
PubChem CID 25151504
Search Google for chemical match using the InChIKey ZCIGNRJZKPOIKD-CQXVEOKZSA-N
Search Google for chemicals with the same backbone ZCIGNRJZKPOIKD
Search PubMed clinical trials cobicistat
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Wikipedia Cobicistat
Comments
This compound is approved as a component of the so-called 'Quad pill' (Stribild®), an anti-HIV therapy which contains cobicistat, elvitegravir, emtricitabine, and tenofovir.