N-desalkylquetiapine

Ligand id: 7545

Name: N-desalkylquetiapine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 52.93
Molecular weight 295.11
XLogP 4.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-piperazin-1-ylbenzo[b][1,5]benzothiazepine
Synonyms
norquetiapine
Database Links
PubChem CID 11369918
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Comments
N-desalkylquetiapine is an active metabolite of the antidepressant quetiapine. N-desalkylquetiapine is approximately 100-fold more potent than quetiapine in inhibition of the norepinephrine reuptake transporter (NET) [1-2]. This acts to increase dopamine levels in the frontal cortex and adds to the compound's antidepressant effect [1,3].