lanicemine

Ligand id: 7681

Name: lanicemine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 38.91
Molecular weight 198.12
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(1S)-1-phenyl-2-pyridin-2-ylethanamine
International Nonproprietary Names
INN number INN
7943 lanicemine
Synonyms
AR-R15896AR | ARL 15896 | AZD-6765 | AZD6765
Database Links
CAS Registry No. 153322-05-5 (source: SciFinder)
ChEMBL Ligand CHEMBL467084
PubChem CID 9794203
Search Google for chemical match using the InChIKey FWUQWDCOOWEXRY-ZDUSSCGKSA-N
Search Google for chemicals with the same backbone FWUQWDCOOWEXRY
Search PubMed clinical trials lanicemine
Search PubMed titles lanicemine
Search PubMed titles/abstracts lanicemine
Search UniChem for chemical match using the InChIKey FWUQWDCOOWEXRY-ZDUSSCGKSA-N
Search UniChem for chemicals with the same backbone FWUQWDCOOWEXRY
Wikipedia Lanicemine
Comments
Lanicemine (AZD 6765) was originally developed as a neuroprotective agent, but was repurposed as an antidepressant with potential for the management of severe and treatment-resistant depression [3]. However, the compound failed to meet study endpoints, so development was halted. The compound is discussed in the AZ 2014 review paper [1].
The structure represented here shows stereochemistry identical to the INN record wheras PubChem CID 3038485 represents the non-chiral molecule.